Adding Zytiga (abiraterone) to conventional hormonal treatments eliminated or nearly eliminated the prostate cancer in one-third of men with this often-lethal form, according to new research to be presented at next month’s annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

“This is one of the first — if not the first — study to show that you can make prostate cancer in the prostate gland itself disappear in a reproducible number of patients,” ASCO official Dr. Nicholas Vogelzang said at a Wednesday press conference.

Commenting on the findings, Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, said, “This is exciting. It’s a novel way to eliminate cancer before surgery.”

However, Brooks, who was not involved in the study, cautioned that the findings were still preliminary and need further investigation.

Trying to shrink a tumor with chemotherapy and/or radiation before surgery is standard for other types of cancer, such as breast or colon, but hasn’t to date shown a benefit in prostate cancer, study author Dr. Mary-Ellen Taplin, associate professor of medicine at Harvard Medical School and Dana-Farber Cancer Institute in Boston, explained at the news conference.

Localized high-risk prostate cancer, which is defined as prostate cancer in men with a prostate-specific antigen level above 20, high-grade disease (a Gleason score of 8 or more), and stage T3 disease (indicating the tumor has spread through the prostate), carries with it a poor prognosis.

Standard hormonal therapy, which stops the production of male hormones (androgens), has not been shown to be effective in this type of cancer when given before surgery. Nor has the surgery, which removes the entire prostate.

Zytiga blocks production of testosterone, which can promote the growth of prostate cancer cells, but in a different way than established hormonal treatments.

This small, phase 2 trial involved 56 men with an average age of 58, all of whom had had at least three positive biopsies for prostate cancer.

For the first three months, 27 men received the standard hormonal therapy leuprolide alone, followed by leuprolide plus Zytiga for another three months.

The remaining 29 men received the two-drug combination for the whole six months, after which all men in both groups underwent prostate surgery.

One-third of the men who had received leuprolide plus Zytiga for the entire six months saw complete or nearly complete elimination of their cancer.

By comparison, only 15 percent of men in the other group experienced these results, the investigators found.

Those who received the combination for only 12 weeks had much lower response rates.

The participants also received low doses of the steroid prednisone to prevent side effects from Zytiga, although side effects overall were minimal, said Taplin.

It’s not clear at this point why some men responded to the combination therapy while others did not, and that is an area that needs to be studied, the researchers said.

“In highly select people who have this aggressive type of prostate cancer, I think this is an important area to investigate,” Brooks noted. “We need to figure out which patients would potentially benefit.”

According to study author Taplin, the research received some funding from Johnson & Johnson, the maker of Zytiga. She said the drug is currently U.S. Food and Drug Administration-approved for patients with advanced prostate cancer that does not respond to hormone therapy, and costs about $5,000 per month.

The data and conclusions of research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Cancer Institute has more on treatments for prostate cancer.

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FILE – This Sept. 18, 2008 file photo shows Mary Richardson Kennedy, the estranged wife of Robert F. Kennedy Jr., in New York. An attorney on Wednesday, May 16, 2012 said Mary Kennedy has been found dead on Robert F. Kennedy Jr.’s property in Bedford, N.Y. (AP Photo/Andy Kropa, File)

FILE – This Sept. 18, 2008 file photo shows Mary Richardson Kennedy, the estranged wife of Robert F. Kennedy Jr. in New York. An attorney on Wednesday, May 16, 2012 said Mary Kennedy has been found dead on Robert F. Kennedy Jr.’s property in Bedford, N.Y. (AP Photo/Andy Kropa, File)

FILE – In this Aug. 29, 2009 file photo, Robert F. Kennedy Jr. and his wife Mary arrive during funeral services for U.S. Senator Edward Kennedy at the Basilica of Our Lady of Perpetual Help in Boston. An attorney on Wednesday, May 16, 2012 said Mary Kennedy has been found dead on Robert F. Kennedy Jr.’s property in Bedford, N.Y. (AP Photo/Brian Snyder, Pool, File)

FILE – In this Feb. 3, 2009 file photo, Robert F. Kennedy Jr., right, and wife Mary Richardson Kennedy arrive at the premiere of “The Pink Panther 2″ at the Ziegfeld Theatre in New York. An attorney on Wednesday, May 16, 2012 said Mary Kennedy has been found dead on Robert F. Kennedy Jr.’s property in Bedford, N.Y. (AP Photo/Peter Kramer, File)

FILE – In this May 6, 2004 file photo, Robert F. Kennedy Jr., right, and his wife Mary Richardson Kennedy arrive at the Natural Resources Defense Council, or N.R.D.C., fundraiser in Los Angeles. An attorney on Wednesday, May 16, 2012 said Mary Kennedy has been found dead on Robert F. Kennedy Jr.’s property in Bedford, N.Y. (AP Photo/Chris Urso, File)

BEDFORD, N.Y. (AP) ? Robert F. Kennedy Jr.’s estranged wife, Mary Richardson Kennedy, who had fought drug and alcohol problems, was found dead at the family property Wednesday.

An autopsy for the 52-year-old was scheduled for Thursday, and no cause of death had been released.

In a statement issued by Robert Kennedy Jr.’s chief of staff, the family said Mary Kennedy, an architect, “inspired our family with her kindness, her love, her gentle soul and generous spirit.”

“Mary was a genius at friendship, a tremendously gifted architect and a pioneer and relentless advocate of green design who enhanced her cutting edge, energy efficient creations with exquisite taste and style,” the family said.

The former Mary Richardson, a longtime connection of the Kennedy clan, married Robert Kennedy Jr., a prominent environmental lawyer and the son of Sen. Robert F. Kennedy and nephew of President John F. Kennedy, in 1994. The couple had four children, the youngest born in July 2001. Robert Kennedy Jr. also has two children from a previous marriage.

Mary Kennedy also was a designer and had overseen the renovation of the couple’s home into an environmentally advanced showpiece. Her family cited her devotion to her children in remembering her.

“We deeply regret the death of our beloved sister Mary, whose radiant and creative spirit will be sorely missed by those who loved her,” the family said in a statement issued by attorney Kerry Lawrence, who had represented her in a drunken-driving case. “Our heart goes out to her children who she loved without reservation.”

Neighbor Leslie Lampert, who owns the Cafe of Love restaurant a short drive from the Kennedy home, said Mary Kennedy was “at all times just a lovely individual.”

“She was community oriented,” Lampert said. “She was always kind in our presence.”

Another neighbor, Kim Fraioli, a trauma therapist who lives a few houses down from the Kennedys, said the family was private.

“We left them alone,” Fraioli. “We didn’t have any interaction. I think it’s a tragedy. It’s very sad for their family and the surviving children. My heart goes out to the family.”

At the home on Wednesday, a red brick mansion with a columned porch entrance set in a heavily wooded acreage, police kept media away.

Mary Richardson had known the Kennedys for years, through her friendship with Robert Kennedy Jr.’s sister, Kerry Kennedy, whom she met at boarding school. She had been Kerry Kennedy’s maid of honor at her wedding in 1990.

She had had trouble with drugs and alcohol and had two high-profile arrests around the time her husband filed for divorce in 2010.

Kennedy was first arrested May 15 of that year on a charge of driving while intoxicated after a police officer reported seeing her drive her car over a curb near the family’s Bedford home. Her only passenger was a dog, and police said she had a blood-alcohol level of 0.11 percent; the legal limit is 0.08 percent. Her license was suspended.

At the time of her sentencing, famous family and friends spoke out in support of her.

Her mother-in-law, Ethel Kennedy, wrote in a letter that she “is a caring, nourishing mother who has nursed her four children through lifelong bouts of debilitating allergies,” according to an account in Westchester’s The Journal News at the time.

Kerry Kennedy, in her letter, said, “When I look at my three daughters, my wish for them is that they are as blessed as I have been to have a companion, a confidante, a friend, like Mary Richardson.”

Mary Kennedy was charged later that year with driving under the influence of drugs, but that charge was dismissed in July 2011 when a judge said the evidence showed she didn’t know the medications she had taken would impair her ability to drive.

There were indications her troubles started earlier. In 2007, Robert F. Kennedy Jr. drove his wife to a hospital for treatment, but she resisted and ran from the car, according to the Journal News, which cited Mount Kisco police records.

“I remember she was acting kind of out of it, kind of crazy,” a witness, Rae Kesten, told The Journal News in 2007. “She was running into the street and flailing her arms around. He was trying to restrain her. I didn’t know if they were fighting or not, but I was concerned.”

The unexpected death of another person connected to the storied Kennedy clan brought to mind the other sorrows the famous family has suffered, including the assassinations of RFK and JFK in the 1960s.

Shopping in Bedford, Diane Glokler said, “I’ve always just thought that family is very tragic. They keep having tragic things happening to them. It’s heart-wrenching.”

___

Associated Press writer Verena Dobnik contributed to this report.

Associated Press

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Make your first call to Michael Seward at 413-531-7129 if you are looking to buy or sell a home in western Mass.

REALTORS? from across the country converged on Washington D.C. for a rally to protect homeownership.? The National Association of REALTORS? (NAR) has been working to make home ownership in America more attainable for over 100 years.? In 1900, fewer than 50% of Americans owned their home.?? Today that number is closer to 70%.

Members of NAR are rallying today to make sure that Congress understands the issues important to homeowners. These include taxation, real estate finance, property insurance, appraisal issues, and commercial real estate related issues.

Taxation

• The Mortgage Interest Deduction (MID)-REALTORS? are working to??? protect the mortgage interest tax deduction that homeowners take on their federal income taxes.
• Capital Gains-When a homeowner sells their primary residence, the profit that they make from the sale of their home (up to $250K for a single person and $500K for married couples) is not taxed. REALTORS? are working to protect this benefit.
• Property Tax Deduction-REALTORS? oppose any changes that would reduce or change current laws.